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Decreased SOD activity is correlated with heightened levels of oxidative damage, encompassing membrane lipid peroxidation, protein carbonylation, and DNA fragmentation [32]

It has been reported that E2 protects against oxidative stress by promoting the production of mitochondrial antioxidant enzymes (SOD2, GPX), increasing levels of antioxidants, and reducing abundance of free radicals in various organs and cells [16]

Another study by Rambo et al., evaluated the effects of acute creatine administration (300 mg/kg orally) on intraperitoneal PTZ-induced electrographic, oxidative, and neurochemical alterations, and mitochondrial membrane potential in rat cerebral cortex (Rambo et al., 2013)

10.3390/ijms23020996 145 YangX